Updated Guidance Shows How Hospitals Should Protect Patients from Resistant Infections

A group of five medical organizations have released updated recommendations for the prevention of methicillin-resistant Staphylococcus aureus, known as MRSA, transmission and infection. MRSA causes approximately 10% of hospital-associated infections in the United States and such infections are associated with an increased risk of death. Certain infections caused by MRSA rose by as much as 41% during the pandemic after falling in preceding years.

Strategies to Prevent Methicillin-Resistant Staphylococcus aureus Transmission and Infection in Acute Care Hospitals provides evidence-based, practical recommendations to prevent the spread of MRSA and reduce the risk of MRSA infection. The document, published today in the journal Infection Control & Hospital Epidemiology, is the most recently updated guidance in the series known collectively as the Compendium.  

“The enormous strain put on healthcare during the pandemic may have contributed to the observed increase in some hospital infections. We have data that show MRSA infections rose,” said David Calfee, M.D., senior author of the updated guidance and editor of ICHE, the journal of the Society for Healthcare Epidemiology of America. “The evidence that informs these recommendations shows that we can be successful in preventing transmission and infection. We can get back to the pre-2020 rates and then do even better.”

The updated recommendations elevate antimicrobial stewardship – an effort focused on improving how antibiotics are prescribed and used – from an “additional practice” to an “essential practice,” meaning all hospitals should do it. When someone who is colonized with MRSA receives treatment with antibiotics for another infection, they may have a higher risk of developing MRSA infection and may be more likely to transmit MRSA to others. Avoiding unnecessary use of antibiotics may decrease these and other risks associated with antibiotic use, such as C. difficile infection.

The guidance describes other practices — surveillance to detect asymptomatic MRSA carriers and decolonization to eradicate or reduce the burden of MRSA among people who are colonized with MRSA — for specific patient populations.

“Basic infection prevention practices, such as hand hygiene and cleaning and disinfection of the healthcare environment and equipment, remain foundational for preventing MRSA,” Calfee said. “These fundamental practices help to prevent the spread of other pathogens as well.”

The authors retained contact precautions, the use of a gown and gloves when providing care to a patient with MRSA colonization or infection, as an essential practice. However, the authors acknowledge that for a variety of reasons some hospitals have chosen to modify or may be considering modification of the use of contact precautions for all or some patients who are colonized or infected with MRSA. The updated recommendations provide guidance to help such hospitals assess risk, make informed decisions, monitor outcomes associated with changes in the use of contact precautions, and identify populations and scenarios in which continued use of contact precautions should be considered.

MRSA infection is caused by a type of staph bacteria that is resistant to many of the antibiotics used to treat ordinary staph infections. Healthcare-associated MRSA infections often follow invasive procedures, such as surgeries, or the use of devices, such as central venous catheters, and can be spread within hospitals by the hands of healthcare personnel or through contact with contaminated surfaces and equipment.

The guidance updates the 2014 Strategies to Prevent Methicillin-Resistant Staphylococcus aureus Transmission and Infection in Acute Care Hospitals. The Compendium, first published in 2008, is sponsored by the Society for Healthcare Epidemiology (SHEA). It is the product of a collaborative effort led by SHEA, with the Infectious Diseases Society of America, the Association for Professionals in Infection Control and Epidemiology, the American Hospital Association, and The Joint Commission, with major contributions from representatives of several organizations and societies with content expertise. The Compendium is a multiyear, highly collaborative guidance-writing effort by over 100 experts from around the world.

In the coming weeks, a new Compendium section will be published outlining approaches to the implementation of infection prevention strategies, followed by an update to strategies to prevent catheter-associated urinary tract infections.

Recently published Compendium updates include strategies for preventing surgical site infections, central line-associated bloodstream infections, ventilator and non-ventilator associated pneumonia and events, C. difficile infection, and strategies to prevent healthcare-associated infections through hand hygiene.

Each Compendium article contains infection prevention strategies, performance measures, and approaches to implementation. Compendium recommendations are derived from a synthesis of systematic literature review, evaluation of the evidence, practical and implementation-based considerations, and expert consensus.

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About Infection Control & Hospital Epidemiology
Published through a partnership between the Society for Healthcare Epidemiology of America and Cambridge University Press, Infection Control & Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 24^th out of 94 Infectious Disease Journals in the latest Web of Knowledge Journal Citation Reports from Thomson Reuters.

About the Society for Healthcare Epidemiology of America (SHEA) The Society for Healthcare Epidemiology of America (SHEA) is a professional society representing more than 2,000 physicians and other healthcare professionals around the world who possess expertise and passion for healthcare epidemiology, infection prevention, and antimicrobial stewardship. The society’s work improves public health by establishing infection-prevention measures and supporting antibiotic stewardship among healthcare providers, hospitals, and health systems. This is accomplished by leading research studies, translating research into clinical practice, developing evidence-based policies, optimizing antibiotic stewardship, and advancing the field of healthcare epidemiology. SHEA and its members strive to improve patient outcomes and create a safer, healthier future for all. Visit SHEA online at shea-online.org, facebook.com/SHEApreventingHAIs and twitter.com/SHEA_Epi.

Contact: Christine Vaughan / cvaughan@thereisgroup.com / 703-587-6177