Fighting bacteria with bacteria: Impact of microbiome therapeutic SER-109 against recurrent CDI

Reviewed by Hannah Imlay, MD, MS, University of Utah

The impact of SER-109, an oral microbiome therapy comprised of purified Firmicutes spores intended to reduce recurrent C. difficile infection (CDI), was recently reported at 4, 12, and 24 weeks. SER-109 was given after use of standard antibiotic treatment of C. difficile infection (CDI) and reduced the rate of recurrent CDI (vs placebo) by week 8 in ECOSPOR III among adults with recurrent CDI. Results showed that 21.3% of patients in the SER group vs. 47.3% of patients in the placebo group had recurrent CDI through 24 weeks; the majority (65%) had a recurrence by week 4, with only 6% of recurrences occurring between week 12 and 24. There were no substantial differences in AEs or serious AEs in the SER-109 group. 

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