Don’t forget about HPV! Population impact of vaccination on HPV detection in cervicovaginal and penile samples

Reviewed by Hannah Imlay, MD, MS, University of Utah

In a population prevalence study (NHANES network), use of quadrivalent human papillomavirus (HPV) vaccination among females and males was associated with lower detection of vaccine strains of HPV in cervicovaginal and penile specimens. In the post-vaccine era, a higher proportion of females vs males received at least 1 HPV dose (25-60% in females vs 14-30% of males). Among sexually experienced females 14-24 years old, there was an 85% reduction in detection of vaccine type HPV strains (90% among vaccinated females, 74% among unvaccinated females). There was no change in prevalence to non-vaccine types of HPV. Vaccine effectiveness was 51% for males overall (not substantially different between vaccinated and unvaccinated males).

Rosenblum HG, Lewis RM, Gargano JW, Querec TD, Unger ER, Markowitz LE. Human Papillomavirus Vaccine Impact and Effectiveness Through 12 Years After Vaccine Introduction in the United States, 2003 to 2018. Ann Intern Med. 2022 Jul;175(7):918-926. doi: 10.7326/M21-3798. Epub 2022 May 17. PMID: 35576590.

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