This document presents guidelines for developing institutional programs to enhance antimicrobial stewardship, an activity that includes appropriate selection, dosing, route, and duration of antimicrobial therapy. The combination of effective antimicrobial stewardship with a comprehensive infection control program has been shown to limit the emergence and transmission of antimicrobial‐resistant bacteria and reduce healthcare costs without adversely impacting quality-of-care. These guidelines focus on the development of effective hospital‐based stewardship programs and do not include specific outpatient recommendations. The population targeted includes all patients in acute care hospitals.

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